Endocrine Abstracts

An 82-year-old male was referred to the breast clinic with a four month history of painful right gynaecomastia (GM), without nipple discharge. A 4 cm plaque of tender, soft tissue was palpable. Physical examination and external genitalia were normal. There was no relevant drug history. Prolactin, Testosterone (T), CXR, Ultrasound and FNA of the breast were normal. LH 13.0 IU (1.5-10.0) and FSH 18.1 IU (1.5-10.0) were raised. FT3 was raised at 7.3 pmol/L (3.5-5.5) with TSH supp...

Objective: Despite being the most common endocrine malignancy, the management of thyroid cancer in the UK remains sub-optimal, with reduced survival rates compared with Western Europe. The British Thyroid association published national guidelines in March 2002 to help standardize and improve the management and survival of thyroid cancer in the UK. We have audited the management of thyroid cancer in a large district hospital comparing the results to the standards set by the Bri...

Objective: Despite being the most common endocrine malignancy, the management of thyroid cancer in the UK remains sub-optimal, with reduced survival rates compared with Western Europe. The British Thyroid association published national guidelines in March 2002 to help standardize and improve the management and survival of thyroid cancer in the UK. We have audited the management of thyroid cancer in a large district hospital comparing the results to the standards set by the Bri...

Introduction: Profound thyrotoxicosis commonly presents with heat intolerance, sweating, weight loss, palpitations, tremor, goitre and eye signs in the case of Grave’s disease. Typically, thyroid storm is differentiated by marked volume depletion, congestive cardiac failure, cardiac arrhythmias, confusion, nausea and vomiting, often with extreme agitation. The wide-ranging and systemic manifestations associated with profound hyperthyroidism are mediated through the thyroi...

Background: Prednisolone is used for glucocorticoid replacement therapy in Adrenal Insufficiency. Package inserts indicate that prednisolone should be administered with or after food as there is a belief that prednisolone causes stomach ulcers. We have investigated the impact of various fasted and non-fasted states on its pharmacokinetic profile.Method: A healthy volunteer provided three 4 mg prednisolone profiles. The first was a fasted reference curve....

Background: Obesity exacerbates a number of chronic inflammatory diseases including asthma, with increasing adiposity observed to worsen asthma severity and disease control. This exacerbation may arise as gut-derived bacterial fragments (endotoxin) and associated markers of endotoxin (lipopolysaccharide binding protein (LPB)), enter the circulation through a damaged gut barrier, provoking systemic inflammation. This study investigated the role of body weight on gut permeabilit...